s41420-025-02799-w
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DATE 08 Dec 2025
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About This Document
Document Type: This is a Study Notes, designed for Reviewing core curriculum material.
Context: Standard material from the 2025 academic period.
Key Content: Likely covers essential definitions, technical implementation, and theoretical concepts necessary for mastery of the subject.
Study Strategy: Summarize these notes into flashcards or mind maps to aid active recall and long-term retention.
Recommendation: comprehensive resource for students aiming to deepen their understanding of General Studies.
Detailed Content Overview
Introduction
This notes resource titled "s41420-025-02799-w" provides comprehensive exam preparation materials designed to test and enhance your understanding. This resource is structured to facilitate effective learning and retention of important information.
Key Topics Covered
Learning Objectives
- Master key concepts required for examination success
- Practice answering exam-style questions effectively
- Develop time management skills for timed assessments
- Identify and address knowledge gaps in understanding
Detailed Summary
com/cddiscovery ARTICLE OPEN HOXA10-TWIST2 antagonism drives partial epithelial-tomesenchymal transition for embryo implantation Nancy Ashary 1, Sanjana Suresh 1, Anshul Bhide 1, Sharmishtha Shyamal 1, Pranya N1, Saee Patil ✉ Anuradha A2, Shruti R. Hansda 2, Harshavardhan BV 3, Mohit Kumar Jolly 4 and Deepak Modi 1 1 , Anuradha Mishra1, © The Author(s) 2025 1234567890();,: In mammalian reproduction, a significant proportion of embryos fail to implant despite a receptive uterus, suggesting that defects in epithelial remodeling at the embryo–uterine interface contribute to implantation failure. The molecular programs enabling such remodeling remain incompletely understood. Here, we identify a conserved transcriptional circuit involving HOXA10 and TWIST2 that regulates epithelial plasticity in the endometrium via partial epithelial-to-mesenchymal transition (pEMT). HOXA10, a transcription factor essential for uterine receptivity, is specifically downregulated in the luminal epithelium at implantation in mice, hamsters, and monkeys. Integrated CUT&RUN and transcriptomic profiling in human endometrial epithelial cells reveal that HOXA10 directly activates epithelial gene networks and represses mesenchymal programs.
Study Tips & Recommendations
Time Management
Practice under timed conditions to improve speed and accuracy. Allocate specific time limits to each section.
Active Practice
Attempt all questions before checking answers. Review mistakes to understand where improvements are needed.
Mark Scheme Review
Study marking schemes carefully to understand how examiners award points and structure your answers accordingly.
Regular Review
Schedule periodic reviews to reinforce learning and combat forgetting. Use spaced repetition for optimal retention.
Content Preview
www.nature.com/cddiscovery ARTICLE OPEN HOXA10-TWIST2 antagonism drives partial epithelial-tomesenchymal transition for embryo implantation Nancy Ashary 1, Sanjana Suresh 1, Anshul Bhide 1, Sharmishtha Shyamal 1, Pranya N1, Saee Patil ✉ Anuradha A2, Shruti R. Hansda 2, Harshavardhan BV 3, Mohit Kumar Jolly 4 and Deepak Modi 1 1 , Anuradha Mishra1, © The Author(s) 2025 1234567890();,: In mammalian reproduction, a significant proportion of embryos fail to implant despite a receptive uterus, suggest...
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